Moreover, the increased expression of cytokines and other inflammatory markers such as IL-1α, beta-defensins 1 and 2, TNF-α, IL-1β, IL-8, IL-10, matrix metalloproteinases MMP-1, MMP-3, MMP-9, CXCL-2 was found in acne lesions in vivo [3], [23]–[26]. The gene discussed is TNF; the disease is acne.