Furthermore, the Th1 polarizing key transcription factor T-bet, Th1 effector cytokine IFN-γ, and Th1 type chemokine receptor CXCR3 were also expressed at a higher level in both acne and psoriasis lesions, indicating the involvement of Th1 effector cells (Figure 8). The gene discussed is IFNG; the disease is psoriasis.