In a previous study, we showed that ESCC was associated with the overexpression of Fascin, which was regulated by phosphorylated Specificity protein 1 (p-Sp1) via activation of the epidermal growth factor (EGF)/extracellular signal-regulated kinase (ERK) signaling pathway [10]. The gene discussed is SP1; the disease is esophageal squamous cell carcinoma.