Furthermore, it has been observed that those obese patients with shorter duration of T2D (less than 5 years), mild forms of T2D (no insulin requirements) and having the greatest body weight loss are more likely to have a remission of T2D when compared with those with longer duration of the disease or chronic T2D (more than 10 years), and are on insulin therapy [91]. The gene discussed is INS; the disease is type 2 diabetes mellitus.