PPARG and Crohn disease: Previous studies have reported that the Ala allele was correlated with lower PPAR-γ transcriptional activity and have characterized the PPAR-γ Pro12Ala polymorphism in a variety of inflammatory diseases, such as type 2 diabetes mellitus, atherosclerosis, ulcerative colitis, Crohn's disease, psoriatic arthritis, and diabetic nephropathy [10–12, 28, 29].