Well-correlating levels of sP-selectin and IL-1β in 50 patients at baseline and a comparable decline after 8 weeks of treatment with either simvastatin (20 mg) or aspirin (100 mg) brought the perception that platelet activation (sP-selectin) in hypercholesterolemia correlates with inflammation (IL-1β) and that both, simvastatin and aspirin lower platelet activation to the same extent but surprisingly only simvastatin lowered the inflammation marker CRP. This evidence concerns the gene IL1B and Hypercholesterolemia.