MPL and familial hypercholesterolemia: Hypercholesterolemia increases the number of circulating neutrophils and monocytes but as well the platelet count by enhanced production via the cholesterol-efflux transporter ABCG4 on megakaryocyte progenitors, which in turn affects cholesterol-sensing LYN- kinase and signaling of the thrombopoietin receptor c-mpl (Murphy et al., 2013).