Also, double null for PTEN and ZBTB7A, for PTEN and TP53 as well as PTEN-null CRPCs with SRD5A1 upregulation and, particularly the tricombo power of Dutasteride further significantly decreased the prostate tumor burden in response to Embelin treatment and ADT (Lunardi et al., 2013). Here, PTEN is linked to prostate neoplasm.