TNF and lung cancer: Luteolin, a polyphenol flavonoid, has been reported to sensitize colorectal cancer cells to TNF-induced apoptosis through suppression of NF- κB. Accumulation of ROS induced by luteolin plays a pivotal role in suppression of NF- κB and potentiation of JNK to sensitize lung cancer cells to undergo TNF-induced apoptosis [331].