Grhl1 and Grhl3, in contrast, are expressed in the embryonic lung epithelium, but later their expression is reduced in bronchi and bronchioles and is undetectable in the alveolar lung epithelium.4,27 The potential relevance of other sequence variants in GRHL2 to sporadic or familial cases of human asthma and other obstructive-airway diseases remains to be determined. The gene discussed is GRHL2; the disease is asthma.