In addition to being expressed in skin, Grhl2 and GRHL2 are highly expressed in the inner ear, the lung epithelium, the ureteric bud of the kidney, the olfactory epithelium, the urogenital tract, the gastric mucosa, and human breast cancer cells.4,8–11,18,27,28 With regard to the clinical phenotype in our affected individuals, aside from the changes affecting the skin and oral mucosa, the other main features comprised deafness and asthma, although this was variably present. This evidence concerns the gene GRHL2 and breast cancer.