VEGF-A proteins also interact with neuropeptides in other tissues, such as somatostatin and angiotensin in the retina (Mei et al., 2012, Wilkinson-Berka, 2004) and kappa opioids in tumor angiogenesis (Yamamizu et al., 2013, Yamamizu et al., 2011) often through common downstream signaling pathways (Pan et al., 2008). This evidence concerns the gene VEGFA and neoplasm.