When considering functionality based on the interpretation of factors involved, development of vitiligo appeared to be associated with the interactions among cytoskeletal factors (OBSCN, ASPM, XIRP1, ADAMTS13), protein kinases (MAPK, ERK1/2, PKC, PRKDC), phosphatase (PPP1CA), ubiquitinylation (UBC) and amyloid (APP) production. Here, XIRP1 is linked to vitiligo.