The results showed that higher expression of NOTCH1 (auto select best cut-off) was associated with poor prognosis and shorter relapse-free survival (RFS; P = 8*10−5, Fig. 1A) in breast cancer but better prognosis and longer overall survival (OS; P=4.4*10−7, Fig. 1B) in lung cancer, with no significant difference in ovarian cancer (data not shown). Here, NOTCH1 is linked to breast cancer.