DPT and hepatocellular carcinoma: To explore the epigenetic regulation of DPT expression in HCC, three HCC cell lines SMMC-7721, Huh7 and MHCC-97H and an immortalized human liver cell line THLE-2, were treated with a demethylating agent 5-aza-2′-deoxycytidine (DAC) and a histone deacetylase inhibitor trichostatin A (TSA) both separately and in conjunction.