CLEC7A and neoplasm: In addition, the control of lung metastasis of B16 cells is equally lost between WT and Dectin-1-deficient mice when NK cells were depleted prior to tumor challenge (Figure 2—figure supplement 6); this result further supports the notion that NK cells are indeed the effector cells and that they need the assistance of DCs and macrophages for which Dectin-1 signaling is critical, in the orchestration for the innate control of tumor cells in vivo.