CLEC7A and neoplasm: Finally, in light of the tenet that innate immunity instructs adaptive immunity (Janeway and Medzhitov, 2002), our study may also raise an interesting issue of whether Dectin-1 signaling by tumor recognition also affects adaptive anti-tumor immune responses, and also may provide new means for the efficient immune responses for cancers such as Dectin-1 agonistic Abs.