However, at the border of active demyelinated WML an increase in CCL2 positive cells was observed (45.3 ± 21.7 cells/mm2; Figure 3E), which was significantly different from the hippocampal WM of control subjects (6.6 ± 9.1 cells/mm2) and WM of myelinated hippocampi of MS patients (8.4 ± 11.6 cells/mm2) (Kruskall-Wallis, p = 0.031; Mann Whitney U, p = 0.004 and p = 0.017, respectively) (Figure 3 M). Here, CCL2 is linked to myeloid sarcoma.