Similarly, the center of active WML (189.8 ± 152.6 cells/mm2) showed significantly more CCR2 positive cells than WM in control hippocampi, WM in myelinated MS hippocampi and the center of inactive WML (20.1 ± 25.2 cells/mm2) (Kruskal-Wallis, p = 0.003; Mann-Whitney U, p = 0.001, p = 0.004 and p = 0.003, respectively). The gene discussed is CCR2; the disease is myeloid sarcoma.