AMFR and colorectal carcinoma: In this study, we showed, for the first time, that AMFR was regulated by miR-139-5p and could promote CRC invasion, and the expression of AMFR protein was negatively correlated with miR-139-5p in CRC tissues, suggesting that the increasing activity of AMFR was due to the inactivation of miR-139-5p in CRC (Figs. 3 and 4).