AMFR and colorectal carcinoma: Several groups have shown that AMFR upregulation correlates with more advanced tumor stage and poor survival in stomach, lung, and breast cancer (Taniguchi et al. 1998; Kawanishi et al. 2000; Jiang et al. 2006), and appears to be a strong independent predictor for recurrence in CRC (Nakamori et al. 1994).