To examine the functional effect of AMFR and NOTCH1 in miR-139-5p-induced metastasis inhibition in CRC cells, we inhibited AMFR and NOTCH1 expression with siRNA (Fig. S6) and revealed that AMFR- and NOTCH1-depleted LoVo cells showed decreased invasion, which phenocopied the invasion-inhibiting effect of miR-139-5p. The gene discussed is AMFR; the disease is colorectal carcinoma.