Patients with renal disease have delayed wound healing as a result of tissue fragility, hypoproteinema, and vascular disorders, as well as more marked aggressive factors such as enhanced acid secretion and increased gastrin levels, and reduced defense factors such as prostaglandins, all of which may be expected to lead to a delay in histological restoration of the ulcer and delayed postoperative bleeding[5,32]. Here, GAST is linked to kidney disorder.