YWHAZ Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Zeta Polypeptide belongs to the 14-3-3 family of proteins which mediate signal transduction [38] and has been suggested as having pivotal role in tumour cell proliferation [63], [64]. The gene discussed is YWHAZ; the disease is neoplasm.