In cystic fibrosis, macrolides improve quality of life and prevent deterioration of lung function [9], in asthma they reduce sputum CXCL8 levels and improve quality of life [10] and in non-cystic fibrosis bronchiectasis and COPD they reduce exacerbations [11], [12]. This evidence concerns the gene CXCL8 and cystic fibrosis.