CCL2 and familial hemiplegic migraine: As for the relationship between MCP-1 and neuropathic pain, Franceschini et al. reported that the trigeminal ganglia of a mouse model of familial hemiplegic migraine (R192Q knock in mouse) had higher mRNA and protein levels of MCP-1; they also reported elevated levels of MCP-1 in the plasma of migraine patients [21]–[23].