Thereby, the aim of this study was to investigate the frequency of rs1800470 (codon 10 T/C), rs1800471 (codon 25 C/G) from the TGF-β, and rs2430561 (+874 T/A) from IFN-γ polymorphisms genotypes in critically ill ICU patients and to analyze the possible impact of these polymorphisms on AKI and death. This evidence concerns the gene IFNG and acute kidney injury.