CRP and chronic kidney disease: Open label, dose escalation observational study in CKD stages 3-4 patients showed statistically significant reductions in creatinine and C-reactive protein, significant improvements in hemoglobin, hematocrit, and physical functioning (QOL measure), trends toward reduction in BUN, potassium, and pain (QOL), and no significant change in mental, emotional, and social well-being [31].