The activation of TLR4 inhibits enterocyte migration and leads to enterocyte apoptosis in mice model, via nuclear factor kappa light chain enhancer of activated B cells (NFκB) pathway activation, whereas the inhibition of TLR4 signaling in the intestinal epithelium prevents NEC development and attenuates the degree of enterocyte apoptosis in mice model and cell cultures [12–14]. This evidence concerns the gene TLR4 and necrotizing enterocolitis.