The median osteopontin level in serum (185 ng/mL) separated mesothelioma patients in those with “low” and “high” expression, showing median survival times of 12.5 and 6.0 months, respectively (hazard ratio 2.45, 95% CI 1.36 to 10.32; Figure 4). Here, SPP1 is linked to mesothelioma.