HSF1 and cancer: Based on previous study, plenty of cancer associated proteins with primary structure change are unstable that can be restored to the native folding by HSP90 including [30–34] apoptotic mediators (Bcl-2, Apaf-1), tumor suppressor genes (Retinoblastoma protein, P53), cell cycle regulatory proteins (CDK4, hTERT), mediators of tissue invasion and metastasis (MMP2) [35], transcription factors (HSF-1, HIF-1), signaling molecules (SRC, LCK, AKT, RAF-1), steroid hormone receptors (androgen, progesterone, glucocorticoid receptors), and mutant fusion kinases (Bcr:abl, Nmp/akl) [36].