Induction of RKIP expression inhibits the activation of signal transducer and activator of transcription 3 (STAT3), NF-κB pathway, and downstream Yin Yang 1 (YY1) as well as antiapoptotic gene products, causing induction of apoptosis in breast and prostate cancer cells [85–87]. This evidence concerns the gene STAT3 and Familial prostate cancer.