A screening of UTI isolates of E. faecalis revealed that tcpF is more frequent among isolates of human urinary tract infections than stool flora, particularly in isolates with bacterial counts of more than 10e5 cfu/mL (P = 0.028). In vitro, TcpF was shown to impair the secretion of proinflammatory cytokines during infection of host cells and to interfere with TLR2 signaling upon intracellular expression, supporting the concept of molecular mimicry, as imposed to this group of proteins. This evidence concerns the gene TLR2 and urinary tract infection.