OT has frequently been examined for its role in modulating anxiety (McCarthy et al., 1996; Windle et al., 1997; Neumann et al., 2000b; Bale et al., 2001; Waldherr and Neumann, 2007; Neumann and Landgraf, 2012) and a recent study has found that OT in the mPFC of virgin male and female rats is anxiolytic (Sabihi et al., 2014). The gene discussed is OXT; the disease is Anxiety.