In these conditions, the DAc derived from iPSC of sporadic PD patients shows morphological (reduced number of neurites and accumulation of autophagic vacuoles) and neurochemical (accumulation of α-synuclein in their cytoplasm) characteristics similar to those of the DAc in PD (Sánchez-Danés et al., 2012). Here, SNCA is linked to Parkinson disease.