The DAc derived from iPSC shows an abnormal phenotype (with respect to aged-matched controls) when produced from patients with familiar parkinsonisms (PINK1, SNCA, parkin, LRRK2...) (Sánchez-Danés et al., 2013) but not when produced from patients with sporadic PD (Soldner et al., 2009). This evidence concerns the gene LRRK2 and Parkinson disease.