The findings are also in line with our earlier studies showing increased IL-18 in the brain of AD patients (Ojala et al., 2009), in turn contributing to many time-dependent protein changes, which can contribute to the pathogenesis of AD, including via NFT and Aβ-plaque formation (Ojala et al., 2008; Sutinen et al., 2012). Here, IL18 is linked to Alzheimer disease.