14-3-3ε can protect against ischemic cerebral infarction and neuronal apoptosis (Wu et al., 2009), but it is also a component of the prion protein amyloid deposits of Gerstmann-Straüssler-Scheinker disease (Di Fede et al., 2007) indicating a role in amyloid regulation in other neurological conditions. The gene discussed is YWHAE; the disease is Gerstmann-Straussler-Scheinker syndrome.