Statistical analysis also indicated that the IL-17F rs763780T>C polymorphisms were significantly associated with cancer risk, particularly gastric cancer (for C versus T: OR = 1.29, 95% CI: 1.14–1.46, P < 0.001, I2 = 0%; for TC versus TT: OR = 1.33, 95% CI: 1.13–1.55, P < 0.001, I2 = 21.6%; for CC versus TT: OR = 1.40, 95% CI: 1.04–1.88, P = 0.026, I2 = 0%; for TC + CC versus TT: OR = 1.34, 95% CI: 1.16–1.55, P < 0.001, I2 = 16% (Figure 3)). Here, IL17F is linked to cancer.