G6PC1 and hepatocellular adenoma: The most effective viral vector reported to date is a recombinant adeno-associated virus vector expressing G6Pase-α directed by the native G6PC promoter/enhancer that effectively extends the lifespan of mice, corrects the metabolic abnormalities and even prevents the development of hepatocellular adenoma (HCA) (Yiu et al., 2010; Lee et al., 2012).