TLR7 and glomerulonephritis: Both the Yaa, derived from SB/Le mice, and TLR7 transgenic models show an increase in the gene copy number and expression of TLR7, which results in a lupus-like disease marked by lymphocyte hyperactivation, ANAs and glomerulonephritis (Deane et al., 2007; Pisitkun et al., 2006).