Genetic studies on human SLE patients also uncovered a number of TLR7 polymorphisms associated with increased disease severity (Kawasaki et al., 2011; Wang et al., 2014), including one showing a TLR7 SNP that leads to a pronounced IFN-I signature (Shen et al., 2010). The gene discussed is TLR7; the disease is systemic lupus erythematosus.