Nevertheless, it is of particular interest that the localized aneurysms- and telangiectasia-like vascular lesions in Crb1rd8/rd8 mice were clinically similar to retinal telangiectasia or Coats-like vasculopathy in patients with CRB1 mutations and that the manifestation of these lesions in humans also seems to be dependent on genetic modifying factors (6,7). The gene discussed is CRB1; the disease is Telangiectasia.