CRB1 and aneurysm: Nevertheless, it is of particular interest that the localized aneurysms- and telangiectasia-like vascular lesions in Crb1rd8/rd8 mice were clinically similar to retinal telangiectasia or Coats-like vasculopathy in patients with CRB1 mutations and that the manifestation of these lesions in humans also seems to be dependent on genetic modifying factors (6,7).