Similar to MTHFR C677T polymorphism, the presence of MTHFR A1298C polymorphism did not associate with an altered overall NHL risk (homozygous: OR = 1.21, 95% CI = 0.97–1.50; heterozygous: OR = 1.02, 95% CI = 0.95–1.09; recessive: OR = 1.21, 95% CI = 0.98–1.49; dominant: OR = 1.05, 95% CI = 0.96–1.14 and allele comparing: OR = 1.08, 95% CI = 0.98–1.18). The gene discussed is MTHFR; the disease is non-Hodgkin lymphoma.