In breast cancer, both SIRT1 and DBC1 expressions were associated with tumor progression and a poor prognosis [14], whereas another study indicated that SIRT1 and DBC1 expressions were associated with favorable and unfavorable clinicopathological factors, suggesting their pleiotropic functions as a potential tumor promoter and tumor suppressor during tumorigenesis [25]. Here, SIRT1 is linked to breast carcinoma.