NAMPT and cancer: Regardless of intrinsic complex biologically function with differential roles as secreted proinflammatory cytokine (extracellular NAMPT) or rate-limiting NAD+ synthesis enzyme (intracellular NAMPT), we looked into the prognostic power with the gene sets regulated by NAMPT. Firstly we confirmed the critical role of NAMPT in carcinogenesis by the gene ontology analysis of all NAMPT-mediated genes: eight of the eleven significantly deregulated pathways are direct cancer pathways (Fig. 1).