RNLS and Nephropathy: Renalase concentration in patients with CKD correlates with increased plasma norepinephrine levels, systolic blood pressure and proteinuria, suggesting that this protein plays an important role in the metabolism of catecholamines, participates in the development of hypertension and cardiovascular disorders, and may directly or indirectly contribute to kidney damage [74] and increased mortality of CKD patients [75, 76].