TBL1XR1 is involved in multiple pathways, including the Wnt/β-catenin, Notch, NF-κB, and nuclear receptor pathways [10–13], The activation of NF-κB signaling is associated with anti-apoptotic properties, and we investigated whether TBL1XR1 promoted anti-apoptotic effects in NPC cells via this pathway. Here, TBL1XR1 is linked to nasopharyngeal carcinoma.