Furthermore, the hepatic transcriptional cofactor, TBL1/TBLR1, was found to regulate liver lipid metabolism via the nuclear receptor peroxisome proliferator-activated receptor (PPAR)α, and the deficiency of TBL1/TBLR1 activity induced liver steatosis and hypertriglyceridemia [16]. Here, TBL1XR1 is linked to hypertriglyceridemia.