When heat stroke was left untreated (control group), solute concentrations rose with time, and TNF-α and IL-10 concentrations were significantly higher at 1, 2, and 3 h, IL-6 and creatinine concentrations were significantly higher at 2 and 3 h, and BUN concentrations were significantly higher at 3 h compared to 0 h. Here, TNF is linked to Heat Stroke.