Furthermore, phenotypes such as cerebellar ataxia, pancytopenia and epidermal hyperpigmentation seen in Rpl27a mutant mice was rescued in a haploinsufficient Trp53 background (Terzian et al., 2011), whereas the dark skin as a result of p53-dependent epidermal melanocytosis seen in Rps6, Rps19, or Rps20 mutant mice was also rescued by Trp53 deletion (McGowan et al., 2008). This evidence concerns the gene RPS6 and Pancytopenia.