Whole body necropsy revealed that out of 14 Rps27l−/−;Trp53+/− mice died within a period of 400 days (50% death rate), seven developed T-lymphoblastic lymphoma (Figure 8C,D), one developed T-cell lymphoma detected in tissues of thymus, lymph node and spleen (Figure 8—figure supplement 1A), and one developed B-cell lymphoma seen in a much enlarged lymph node (Figure 8—figure supplement 1B). This evidence concerns the gene TP53 and T-lymphoblastic lymphoma.