Clinical staging of AD corresponds with spread of tau pathology (formation of typical argyrophilic neurofibrillary tangles and neuropil threads within the neurons) characterized in Braak staging [34], where stage I-IV corresponds with the spread of pathology in the direction from transentorhinal and parahippocampal cortices, to hippocampus, fusiform gyrus and beyond [35]. The gene discussed is MAPT; the disease is Alzheimer disease.