S100A8 and gastric cancer: Fig. 5B shows the migrated cell numbers of SGC-7901 in CagA transfection group are obviously more than control group, while the amount of migrated cell in co-transfection group is significantly less than CagA transfection group. The biological phenomena demonstrate EMT promotion by CagA was recovered in part by elevated PDCD4 expression. On the basis of evidence, it inferred that PDCD4 may be required for H. pylori CagA-mediated gastric cancer progression.