This is reminiscent of Rpn11 and BRCC36 (for BRCA1 (for Breast Cancer 1)/BRCA2 (for Breast Cancer 2)-Containing Complex subunit 36) found in the 26S proteasome lid and BRCC36-containing complexes, respectively, that are also inactive in the stand-alone form [20]. Here, BRCA2 is linked to breast cancer.