SH3BP2 and arthritic joint disease: The incidence of arthritis at day 42 was comparable between Sh3bp2+/+ and Sh3bp2KI/+ mice (73.3% vs. 71.4%, respectively) (Figure 2B), although Sh3bp2KI/+ mice showed a tendency of earlier development compared with Sh3bp2+/+ mice (P = 0.13 at day 28 and P = 0.14 at day 31).