Thus, MRJP1 feeding induces a significant increase in liver bile acids and a tendency to increase in CYP7A1 mRNA with a concomitantly significant increase in fecal bile acids excretion, indicating that the stimulation of cholesterol catabolism form part of the mechanism by which MRJP1 induces hypocholesterolemia. Here, CYP7A1 is linked to Hypocholesterolemia.