To further rule out the influence of NPPA rs5063 and MTHFR rs1801133 on blood pressure and subsequently on ischemic stroke and cerebral hemorrhage, we tested the interaction of NPPA rs5063 and MTHFR rs1801133 with hypertension status in control population, and we did not find any interaction with hypertension (data not shown). This evidence concerns the gene MTHFR and hypertensive disorder.