After adjustment for age, sex, BMI and hypertension status, ORs of NPPA rs5063 (95% CI; P value) were 0.69 (0.52–0.90; 0.006) for ischemic stroke and 0.39 (0.19–0.78; 0.007) for cerebral hemorrhage respectively. The gene discussed is NPPA; the disease is Hypertension.