MTHFR and ischemic stroke: We further individually tested the association of NPPA rs5063 and MTHFR rs1801133 with ischemic stroke and cerebral hemorrhage in the hypertension and non-hypertension groups and found that NPPA rs5063 was associated with both ischemic stroke and cerebral hemorrhage in the hypertension group, In non -hypertension group, the association between NPPA rs5063 and ischemic stroke and cerebral hemorrhage did not reach significance but the effect size and directions were the same as in hypertension group.