NPPA and Stroke: Rubattu et al [22] reported that in a matched, case-control study, NPPA rs5063 polymorphism was associated with the occurrence of stroke (348 strokes and 348 controls) under additive (OR, 1.9; 95% CI, 1.16 to 3.12; P = 0.01) and dominant model (OR, 2.0; 95% CI, 1.17 to 3.39; P = 0.01).