We also found that NPPA rs5063 was associated with cerebral hemorrhage and ischemic stroke and MTHFR rs1801133 was associated with cerebral hemorrhage in the hypertension group and MTHFR rs1801133 was associated with cerebral hemorrhage in the non-hypertension group and were not directly associated with hypertension. This evidence concerns the gene MTHFR and ischemic stroke.