We further individually tested the association of NPPA rs5063 and MTHFR rs1801133 with ischemic stroke and cerebral hemorrhage in the hypertension and non-hypertension groups and found that NPPA rs5063 was associated with both ischemic stroke and cerebral hemorrhage in the hypertension group, In non -hypertension group, the association between NPPA rs5063 and ischemic stroke and cerebral hemorrhage did not reach significance but the effect size and directions were the same as in hypertension group. The gene discussed is NPPA; the disease is Hypertension.