APOE and ischemic stroke: Such as protein kinase C η (PRKCH) [11], angiotensin receptor like-1 (AGTRL1) [12], methylenetetrahydrofolate reductase (MTHFR) [13], and guanine nucleotide exchange factor 10 (ARHGEF10) [14] were associated with ischemic stroke and angiotensin-converting enzyme (ACE) [15], plasminogen activator inhibitor -1(SERPINE1) [15], apolipoprotein E (APOE) [15] and coagulation factor V (FV) [15] were associated with cerebral hemorrhage.