Individuals with HIV-SN of any severity and those who reported neuropathy symptoms other than DNP had a lower CD4 nadir than corresponding controls [median (IQR) for cases vs. controls, respectively, were 112 (31, 246) vs. 242 (125, 391) cells/μL, p<0.01 for at least one HIV-SN sign; 107 (23, 214) vs. 200 (70, 350), p<0.01 for at least two signs; and 151 (37, 275) vs. 198 (60, 348), p<0.01 for neuropathy symptoms]. Here, CD4 is linked to neuropathy.