DKK1 and benign chondrogenic neoplasm: As shown in Figure 2A, the positive signal of DKK1 was preferentially identified at the cytoplasm, and high DKK1 expression was 58.9% (37/63) in chondrosarcomas samples as compared with 23.5% (4/17) in benign cartilage tumors (P = 0.014, Table 1).