Our results shown that the mRNA levels of DKK1 and β-catenin in chondrosarcomas were significantly increased compared with the corresponding non-tumor tissues (P = 0.006, Fig. 1); Similarly, a remarkable elevation in DKK1 and β-catenin protein was also observed in chondrosarcoma as compared to the corresponding non-tumor tissues (Figure 1; P = 0.001, Figure 1). This evidence concerns the gene DKK1 and neoplasm.