We thought that the significant increase in the number of Ki-67-positive hepatocytes in the PVL+ISS group at 48 h was the basis for the higher hepatic regeneration rate in the PVL+ISS group at 72 h and 7 days post-operation, which was consistent with the HRR of the right median lobes. This evidence concerns the gene MKI67 and periventricular leukomalacia.