CYP2W1 and adrenal cortex carcinoma: Considering only ACC samples obtained from primary surgery (n = 196), CYP2W1 immunoreactivity was significantly lower in tumors with a high Ki67 proliferation index (Ki67>10%, n = 59) than in those with low Ki67 (n = 56, P<0.005) and in those with a high Weiss score (Weiss score >6, n = 113) compared to those with low Weiss score (n = 58, P<0.005, Figure 3C and 3D and Table 1).